After a quiet third quarter, Ohio State stunned their host crowd with a 24-hand touchdown attack from CJ Stroud quarterback to Xavier Johnson's breadth recipient.
Johnson beat 1-on-1 coverage for the score that closed an 11-play 70-yard drive.
Notre Dame leads Ohio State 10-7 after two quarter matches.
The Buckeyes had an opportunity to tie the game with 36 seconds remaining in the round, but missed a 39-yard field goal.
Notre Dame has been led by the efficiency of quarterback Tyler Buchner; He passed 8-10 for 128 yards in his first match as a starter.
Notre Dame's flamboyant attack averaged only 2.9 yards per carry in the first half.
Ohio State quarterback C.J. Stroud has 99 passing yards and a touchdown
Stroud has been without his top wide receiver Jackson Smith-Njigba for most of the game